ChemR23 was discovered as an orphan receptor related to the chemoattractant receptors C3a, C5a and FPR1, and expressed on dendritic cells and macrophages. A ligand for ChemR23 was characterized as chemerin, a 15 kD proteolytically processed protein found in inflammatory sites; a 9 amino acid peptide from the C-terminus of chemerin is sufficient to activate ChemR23. Chemerin expressed in lymphoid and microvascular endothelium mediates migration of ChemR23-expressing dendritic cells to lymphoid organs and vasculature at sites of inflammation. In addition, a bioactive lipid, resolvin E1, was found to functionally interact with ChemR23 to reduce inflammation.
Product Information | |
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Catalog #: | ACC-RG0626 |
Gene Name | CMKLR1 |
Abbr | Chem-1-HuCMKLR1/Galpha15 |
Alias | CMKLR1,DEZ,ChemR23,CHEMERINR,MGC126105,MGC126106 |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CMKLR1,DEZ,ChemR23,CHEMERINR,MGC126105,MGC126106 |
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