Hypothalamic corticotropin releasing hormone (CRH) exerts its diverse physiological actions via cell surface G protein-coupled CRH receptors (CRHRs), of which two subtypes (CRHR1 and CRHR2) have been identified. CRH regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress. Overproduction of CRH and stress system abnormalities are associated with psychiatric diseases such as depression, anxiety, eating disorders, and addiction. CRHR1 is expressed in pituitary corticotrophs and the brain. CRH binds to CRHR1 with high affinity, and activation of CRHR1 by CRH increases cAMP intracellular levels and activates protein kinase A. CRHR1 also couples to activation of MAPK as well as protein kinase C in an isoenzyme-specific manner. Selective CRHR1 antagonists offer new possibilities for the treatment of anxiety and depression.

Product Information
Catalog #:	ACC-RG1272
Gene Name	CRHR1
Abbr	CHO-HuCRHR1/Apoaequorin
Alias	CRHR1,CRHR,CRF R,CRF1,CRF-R,CRFR1,CRF-R1,CRFR-1,CRH-R1,CRHR1L,CRHR1f,CRF-R-1,CRH-R-1,CRH-R1h
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	CRHR1,CRHR,CRF R,CRF1,CRF-R,CRFR1,CRF-R1,CRFR-1,CRH-R1,CRHR1L,CRHR1f,CRF-R-1,CRH-R-1,CRH-R1h

Related Products

Catalog	Product Name	Gene Name	Species	Morphology	Price
ACC-RG1666	Human CRHR1 Stable Cell Line-CHO-K1/Gα15	CRHR1	Human		INQUIRY
ACC-RG1728	Human CRHR1 Stable Cell Line-HEK293T Gαqi5	CRHR1	Human		INQUIRY
ACC-RG0270	Human CRHR1-FLAG Stable Cell Line-CHO	CRHR1	Human	Epithelial-like	INQUIRY
ACC-RG0235	Human CRHR1-FLAG Stable Cell Line-HEK293T	CRHR1	Human	Epithelial	INQUIRY
ACC-RG1213	Human CRHR1 Validated Stable Cell Line-CHO	CRHR1	Human	Epithelial-like	INQUIRY