The CRF1 receptor is a Gs-coupled GPCR expressed in the brain and pituitary gland that binds to several neuropeptides, including corticotropin-releasing factor (CRF) and urocortin, and the amphibian peptide sauvagine. CRF plays a predominant role in stress response mediated by the hypothalamic-pituitary-adrenal axis, and alterations in CRF and its receptors CRF1 and CRF2 appear to be linked to depression and anxiety. A number of small molecule antagonists of the CRF1 receptor have been characterized, including R121919, SC241, NBI27914, antalarmin, DMP-696, and CP 154,526. When delivered in animal models of psychiatric disorders, these antagonists display effectiveness in reducing stress-related behaviors.
Product Information | |
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Catalog #: | ACC-RG0648 |
Gene Name | CRHR1 |
Abbr | Chem-1-HuCRHR1/Galpha15 |
Alias | CRHR1,CRHR,CRF R,CRF1,CRF-R,CRFR1,CRF-R1,CRFR-1,CRH-R1,CRHR1L,CRHR1f,CRF-R-1,CRH-R-1,CRH-R1h |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CRHR1,CRHR,CRF R,CRF1,CRF-R,CRFR1,CRF-R1,CRFR-1,CRH-R1,CRHR1L,CRHR1f,CRF-R-1,CRH-R-1,CRH-R1h |
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