CXCR1 (also known as IL-8RA) is a Gi/o-coupled GPCR expressed on neutrophils, CD8(+) T cells, and intestinal epithelial cells. CXCR1 binds with high affinity to the chemokine interleukin-8 (IL-8) and much lower affinity to GROalpha, whereas a related receptor, CXCR2, binds with equal affinity to IL-8 and GROalpha. CXCR1 has been proposed to be the primary regulator of neutrophil response to IL-8 in sepsis. Antagonists of CXCR1 and CXCR2 have been developed and display efficacy in animal models of reperfusion injury.
Product Information | |
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Catalog #: | ACC-RG0638 |
Gene Name | CXCR1 |
Abbr | Chem-1-HuCXCR1/Galpha15 |
Alias | CXCR1,CMKAR1,CD181,CDw128a,CKR 1,CXC-R1,CXCR-1,IL-8R A,C-C,CD128,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CXCR1,CMKAR1,CD181,CDw128a,CKR 1,CXC-R1,CXCR-1,IL-8R A,C-C,CD128,CKR-1,IL8R1,IL8RA,CMKAR1,IL8RBA |
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