The chemokine SDF-1alpha and its GPCR receptor CXCR4 have a one-to-one specificity that is unique among chemokines and their receptors. SDF-1alpha binds to CXCR4 expressed on hematopoietic and lymphopoietic cells, and directs their trafficking to and retention in hemato-and lymphatopoietic organs and sites of inflammation. CXCR4 is expressed on several tumor cell lineages, and might be responsible for metastasis to sites of SDF-1alpha expression, such as bone and lymph nodes. In addition, CXCR4 is a coreceptor for the HIV envelope glycoprotein gp120. Small molecule antagonists of CXCR4 have been developed and shown to inhibit infectivity of T-tropic HIV strains and to impair growth of brain tumors.
Product Information | |
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Catalog #: | ACC-RG0642 |
Gene Name | CXCR4 |
Abbr | Chem-1-HuCXCR4/Galpha15 |
Alias | CXCR4,CD184,HM89,HSY3RR,LESTR,NPY3R,NPYR,NPYY3R,CXC-R4,CXCR-4,FB22,LAP3,LCR1 |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CXCR4,CD184,HM89,HSY3RR,LESTR,NPY3R,NPYR,NPYY3R,CXC-R4,CXCR-4,FB22,LAP3,LCR1 |
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