CXCR5 (also known as BLR1) is a GPCR that binds selectively to the chemokine CXCL13 (also known as BLC and BCA-1) to mediate immune system development and function. CXCR5 cooperates with CCR7 to determine functional organization of lymphoid organs such as lymph nodes and Peyer's patches. In addition, CXCR5 mediates migration of B cells into the follicles of the splenic white pulp, thus permitting antigen deposition on follicular dendritic cells. Patients with rheumatoid arthritis (RA) displayed upregulated expression of CXCR5 to a greater extent than other chemokine receptors, and CXCR5-null mice subjected to antigen-induced arthritis display reduced joint destruction. Therefore, CXCR5 represents a potential target for treatment of rheumatoid arthritis.
Product Information | |
---|---|
Catalog #: | ACC-RG0643 |
Gene Name | CXCR5 |
Abbr | Chem-10-HuCXCR5/Galpha15 |
Alias | CXCR5,BLR1,CD185,MDR15,CXC-R5,CXCR-5,BLR1,MGC117347 |
Growth Properties | Adherent |
Host Cell | Chem-10 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CXCR5,BLR1,CD185,MDR15,CXC-R5,CXCR-5,BLR1,MGC117347 |
Related Products
Catalog | Product Name | Gene Name | Species | Morphology | Price |
---|---|---|---|---|---|
ACC-RG1662 | Human CXCR5 Stable Cell Line-CHO-K1/Gα15 | CXCR5 | Human | INQUIRY | |
ACC-RG0506 | Human CXCR5/Gi Stable Cell Line-CHO | CXCR5 | Human | Epithelial-like | INQUIRY |
ACC-RG0224 | Human CXCR5-FLAG Stable Cell Line-HEK293T | CXCR5 | Human | Epithelial | INQUIRY |
ACC-RG0223 | Human CXCR5-FLAG Stable Cell Line-CHO | CXCR5 | Human | Epithelial-like | INQUIRY |
ACC-RG1467 | Human CXCR5/beta-Arrestin Stable Cell Line-C2C12 | CXCR5 | Human | Myoblast | INQUIRY |
ACC-RG1468 | Human CXCR5/beta-Arrestin Stable Cell Line-CHO | CXCR5 | Human | Epithelial-like | INQUIRY |
Inquiry