CXCR6 (CXC-chemokine receptor type 6) is a receptor for CXC chemokine CXCL16. CXCR6 is expressed by naive CD8 T cells, natural killer T cells, a subset of memory CD4 T cells and plasma cells. CXCR6 and its ligand play an important role in the trafficking of the cells expressing them. It is demonstrated that CXCL16+ macrophages in synovial fluid of rheumatoid arthritis patients lead to
recruitment of CXCR6+ memory T cells, thereby contributing to the inflammatory cascade associated with rheumatoid arthritis pathology. CXCR6 is also used as a coreceptor by simian immunodeficiency viruses (SIVs) and by strains of HIV-2 and M-tropic HIV-1.
Product Information | |
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Catalog #: | ACC-RG0226 |
Gene Name | CXCR6 |
Abbr | CHO-HuCXCR6-FLAG |
Alias | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 |
Growth Properties | Adherent |
Host Cell | CHO-K1 |
Morphology | Epithelial-like |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 |
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