Endothelin is a hormone produced predominantly by endothelial cells that have been recognized to play a significant role in the development of several cardiovascular disease states. Its receptor ETA has been reported in a variety of tissues including placenta, uterus, testis, heart, adrenal gland, lung, kidney, ovary, skin, liver, bladder, large blood vessels, cerebellum, neurons, and meningioma tumor cells. In the vasculature, ETA receptors residing on smooth muscle cells mediate prolonged vasoconstriction. Furthermore, activation of the ETA mediates events that regulate mitogenesis, apoptosis, angiogenesis and metastasis in tumors. The Human EDNRA-FLAG stable cell lines-CHO expresses EDNRA cDNA that is identical to GenBank NM_001957.1 except for 1 mutation that results in a change in amino acid Leu to Val at position 322, which has been reported as a natural variant.

Product Information
Catalog #:	ACC-RG0241
Gene Name	EDNRA
Abbr	CHO-HuEDNRA-FLAG
Alias	EDNRA,ETA,ET-A,ETAR,ETRA,ETA-R,hET-AR
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	EDNRA,ETA,ET-A,ETAR,ETRA,ETA-R,hET-AR

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