The endothelin family of peptides are potent vasoconstrictors synthesized by endothelial cells in both constitutive and inducible pathways. The biological actions of endothelins are mediated by two GPCRs, ETA and ETB. Whereas ETA is the predominant receptor on smooth muscle cells and thus is the primary mediator of the vasoconstrictor activity, ETB is found on endothelial cells and mediates vasodilation. In addition, ETB has also been linked to renal failure, congestive heart failure, atherosclerosis, and pulmonary hypertension. A mutation in ETB has been found to cause Hirschsprung disease-2, a degenerative disease of the digestive tract.

Product Information
Catalog #:	ACC-RG0656
Gene Name	EDNRB
Abbr	CHO-HuEDNRB/Galpha15
Alias	EDNRB,ABCDS,ET-B,ET-BR,ETB,ETBR,ETRB,HSCR,HSCR2,WS4A
Growth Properties	Adherent
Host Cell	CHO
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	EDNRB,ABCDS,ET-B,ET-BR,ETB,ETBR,ETRB,HSCR,HSCR2,WS4A

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