PAR1 is one of the four members of G protein-coupled proteaseactivated receptor family (PAR1, PAR2, PAR3, and PAR4). PAR1 is activated by coagulant protease thrombin via an irreversible proteolytic mechanism: thrombin specifically cleaves the extracellular N-termini of the receptor to unmask a new amino acid terminus, which in turn acts as a peptide ligand by binding intramolecularly to the body of the receptor. An increased thrombin generation and PAR1 expression are observed on cells within atherosclerotic plaque and thrombus and following vascular injury. PAR1 may play important role in thrombosis and restenosis and thus a PAR1 antagonist possesses the therapeutic potential in treating these diseases.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0370||Human F2R Stable Cell Line-CHO||F2R||Human||Epithelial-like||INQUIRY|