FPR1 is a Gi-coupled GPCR that binds and is activated by short, N-formyl peptides, such as N-Formyl-Met-Leu-Phe (fMLF). N-formyl peptides are typically derived from bacteria and mediate host recruitment of leukocytes, which highly express FPR1, to sites of bacterial infection. In addition, FPR1 is expressed in the vasculature, secretory epithelial cells, neurons and other tissues. Other ligands, such as mitochondrially encoded formyl peptides, amyloid proteins, and virus-derived peptides, have also been found to activate FPR1 and/or related GPCRs and may be important in the pathophysiology of amyloidoses, Alzheimer's disease and HIV.
Product Information | |
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Catalog #: | ACC-RG0706 |
Gene Name | FPR1 |
Abbr | Chem-1-HuFPR1/Galpha15 |
Alias | FPR1,FMLP,FPR |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | FPR1,FMLP,FPR |
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