GPR109B (or HM74) is a 387-amino acid, 7-transmembrane protein responsible for the directed migration of specific cell types. GPR109B has highest expression in spleen, lymphocytes and adipose tissue, and lower expression in the heart, placenta, prostate and bone marrow. Nicotinic acid has been used as a lipid-lowering agent possibly by acting through GPR109A and GPR109B in adipose tissues. This supports the suggestion that signaling through this nicotinic acid receptors may be a mechanism for the treatment of hyperlipidemia and insulin-resistant states.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0338||Human HCAR3-FLAG Stable Cell Line-CHO||HCAR3||Human||Epithelial-like||INQUIRY|
|ACC-RG0561||Human HCAR3/Gi Stable Cell Line-CHO||HCAR3||Human||Epithelial-like||INQUIRY|