5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT1A has been implicated in anxiety and depression. Desensitization of 5-HT1A has been correlated with the functional improvements in depression observed 2-3 weeks after initiation of treatment with SSRIs. Decreased 5-HT1A is observed in anxiety disorders, and mice lacking 5-HT1A display increased anxiety. Buspirone, a partial agonist for 5-HT1A , is used clinically for treatment of anxiety disorders.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0383||Human HTR1A-FLAG Stable Cell Line-HEK293T||HTR1A||Human||Epithelial||INQUIRY|
|ACC-RG0552||Human HTR1A/Gi Stable Cell Line-CHO||HTR1A||Human||Epithelial-like||INQUIRY|
|ACC-RG0778||Human HTR1A Stable Cell Line-CHO||HTR1A||Human||Epithelial-like||INQUIRY|
|ACC-RG1530||Human HTR1A/beta-Arrestin Stable Cell Line-CHO||HTR1A||Human||Epithelial-like||INQUIRY|
|ACC-RG1642||Human HTR1A Stable Cell Line-CHO-K1/Gα15||HTR1A||Human||INQUIRY|