5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT1A has been implicated in anxiety and depression. Desensitization of 5-HT1A has been correlated with the functional improvements in depression observed 2-3 weeks after initiation of treatment with SSRIs. Decreased 5-HT1A is observed in anxiety disorders, and mice lacking 5-HT1A display increased anxiety. Buspirone, a partial agonist for 5-HT1A , is used clinically for treatment of anxiety disorders.
Product Information | |
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Catalog #: | ACC-RG0750 |
Gene Name | HTR1A |
Abbr | Chem-3-HuHTR1A/Galpha15 |
Alias | HTR1A,ADRB2RL1,ADRBRL1,G-21,5HT1a,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1 |
Growth Properties | Adherent |
Host Cell | Chem-3 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | HTR1A,ADRB2RL1,ADRBRL1,G-21,5HT1a,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1 |
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