Human 5-HT6 receptors are G protein-coupled receptors. The cDNA encodes a 440-amino-acid polypeptide. The 5-HT6 receptors are expressed exclusively in brain regions such as striatum, cortex, nucleus accumbens, olfactory tubercle, hippocampus, hypothalamus, amygdala and cerebellum. The 5-HT6 receptors appear to regulate GABAergic, glutamatergic and cholinergic neurotransmission and are involved in the regulation of cognition, feeding and sleep/wake regulation. They may also play a role in mediating the effects of some antipsychotic agents, and in modulating sensory gating which is often affected in schizophrenic patients.
Product Information | |
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Catalog #: | ACC-RG1538 |
Gene Name | HTR6 |
Abbr | U2OS-HuHTR6/beta-Arrestin |
Alias | HTR6,5 HT6,5 HT6R,5-HT-6,5-HT6,5-HT6R |
Growth Properties | Adherent |
Host Cell | U2OS |
Morphology | Epithelial |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | HTR6,5 HT6,5 HT6R,5-HT-6,5-HT6,5-HT6R |
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