GPR54 (also known as AXOR12) is a Gq-coupled GPCR that binds to a series of peptides, termed kisspeptins or metastin, derived from the KiSS-1 gene. The KiSS-1 gene inhibits metastatic activity of melanoma and other tumor cell lines, and clinical evidence supports a role for KiSS-1 and GPR54 in inhibition of metastasis in human cancer. Kisspeptins and GPR54 also play a central role in hypothalamic regulation of puberty, by directly governing the release of gonadotropin-releasing hormone from the hypothalamus. In addition, mutations in GPR54 in mice and humans result in hypogonadotropic hypogonadism.
Product Information | |
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Catalog #: | ACC-RG1540 |
Gene Name | KISS1R |
Abbr | C2C12-HuKISS1R/beta-Arrestin |
Alias | AXOR12,GPR54,HH8,HOT7T175,KISS-1R |
Growth Properties | Adherent |
Host Cell | C2C12 |
Morphology | Myoblast |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | AXOR12,GPR54,HH8,HOT7T175,KISS-1R |
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