Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A family of three GPCRs, LPA1, LPA2 and LPA3, mediates the biological effects of LPA. LPA2 is widely expressed, with particularly notable expression in helper T Cells. LPA2 upregulation has been demonstrated in multiple cancer cells, including colon and ovarian cancer. LPA2 couples to multiple signaling cascades through Gq, Gi/o and G12/13, mediating inhibition of adenyl cyclase, inositol phosphate turnover, calcium flux and cell migration.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0446||Human LPAR2-FLAG Stable Cell Line-CHO||LPAR2||Human||Epithelial-like||INQUIRY|
|ACC-RG0284||Human LPAR2-FLAG Stable Cell Line-RH7777||LPAR2||Human||Epithelial||INQUIRY|
|ACC-RG1484||Human LPAR2/beta-Arrestin Stable Cell Line-CHO||LPAR2||Human||Epithelial-like||INQUIRY|