Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A growing family of GPCRs mediates the biological effects of LPA. The first LPA receptors described, LPA1-3, share relatively high sequence similarity and are related to the sphingosine 1-phosphate receptors S1P1-6. Two more recently characterized LPA receptors, LPA4 and LPA6, are related to each other but are more distantly related to LPA1-3. LPA6, originally known as GPR92, mediates LPA-induced cytoskeletal changes, intracellular calcium flux and increased cAMP by coupling to G12/13, Gq, and Gs. In addition to binding LPA, LPA6 is also activated by several other lipid-derived molecules, the most potent of which is farnesyl pyrophosphate. GPR92 is expressed in several tissues, most prominently in the CD8+ intraepithelial lymphocytes of the gastrointestinal tract.
Product Information | |
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Catalog #: | ACC-RG0685 |
Gene Name | LPAR5 |
Abbr | Chem-1-HuLPAR5/Galpha15 |
Alias | LPAR5,GPR92,GPR93,KPG_010,LPA5,LPA-5 |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | LPAR5,GPR92,GPR93,KPG_010,LPA5,LPA-5 |
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