The Mas-related genes (Mrgs), also known as sensory neuron-specific G-protein coupled receptors (SNSRs), are selectively expressed in subpopulations of sensory neurons involved in the perceptor of pain. The Mrg family in rodents consists of 50 receptors in the MrgA-MrgH subfamilies, but humans contain fewer Mrg members. MrgD (also known as TGR7) is found across species from rodents to humans, and its expression is restricted to nonpeptidergic, small-diameter, IB4+ dorsal root ganglion (DRG) neurons. MrgD binds beta-alanine, but not L-alanine, which results in increased intracellular calcium and the suppression of forskolin-induced cAMP production, thus suggesting coupling to Gq and Gi proteins. beta-alanine-induced activation of MrgD inhibits KCNQ2/3-mediated M-currents in cells overexpressing MrgD and KCNQ2/3 and also in cultured DRG neurons, which indicates that MrgD enhances nociceptive signaling.

Product Information
Catalog #:	ACC-RG1249
Gene Name	MRGPRD
Abbr	CHO-HuMRGPRD/Apoaequorin
Alias	MRGPRD,MRGD,TGR7
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	MRGPRD,MRGD,TGR7