Neuromedin U (NmU) is a peptide which regulates peripheral functions such as smooth muscle contraction and blood pressure, and CNS functions including nociception and feeding activity. Two GPCRs, NMU1 and NMU2, mediate the contractile effects of neuromedin U by activation of both Gq and Gi. Compared to the wide distribution of NMU1 in peripheral tissue, expression of NMU2 receptor is limited to areas of the brain, such as the paraventricular nucleus, along the wall of the third ventricle in the hypothalamus and the CA1 region of the hippocampus, and to the spinal cord. Recent study has shown that mice deficient in NMU2 but not NMU1 receptor had impaired nociceptive responses suggesting that the pro-nociceptive effects of NmU in mice appear to be mediated through NMU2.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0323||Human NMUR2-FLAG Stable Cell Line-HEK293T||NMUR2||Human||Epithelial||INQUIRY|
|ACC-RG1185||Human NMUR2 Validated Stable Cell Line-CHO||NMUR2||Human||Epithelial-like||INQUIRY|
|ACC-RG1309||Human NMUR2/Apoaequorin Stable Cell Line-CHO||NMUR2||Human||Epithelial-like||INQUIRY|
|ACC-RG1638||Human NMUR2 Stable Cell Line-HEK293T||NMUR2||Human||INQUIRY|