GPR99 (also known as GPR80) was originally identified as an orphan with a sequence most closely related to P2Y receptors. Studies to deorphanize GPR99 revealed that alpha-ketoglutarate activates GPR99 through Gq to increase intracellular calcium. The EC50 of GPR99 for alpha-ketoglutarate is in the μM range, similar to the concentration of alpha-ketoglutarate in the circulation, indicating that the interaction is physiologically significant.
Product Information | |
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Catalog #: | ACC-RG0612 |
Gene Name | OXGR1 |
Abbr | Chem-1-HuOXGR1/Galpha15 |
Alias | GPR80,GPR99,P2RY15,P2Y15 |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | GPR80,GPR99,P2RY15,P2Y15 |
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