Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGE2 causes pain, vasodilatation, immunosuppression of T cells, bone resorption and promotion of carcinogenesis. Four related GPCRs, EP1, EP2, EP3 and EP4, each bind to PGE2, but the different G protein coupling status of each receptor leads to distinct biological effects. Further diversity is generated by alternative splicing; the human gene for EP3 generates 9 alternatively spliced mRNAs encoding 8 isoforms of EP3. These isoforms of EP3 vary in sequence at their C-termini, and differ in their ability to couple to Gs, Gq or Gi. EP3 is required for fever induced by pyrogens, a response long attributed to prostaglandins by the antipyretic action of aspirin and other COX inhibitors. In animal models of allergy, PGE2-mediated activation of EP3 inhibits inflammation to counteract the allergy-promoting activity of PGE2.
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0361||Human PTGER3-FLAG Stable Cell Line-CHO||PTGER3||Human||Epithelial-like||INQUIRY|
|ACC-RG0577||Human PTGER3/Gi/Go Stable Cell Line-CHO||PTGER3||Human||Epithelial-like||INQUIRY|
|ACC-RG0739||Human PTGER3/Galpha15 Stable Cell Line-Chem-1||PTGER3||Human||INQUIRY|
|ACC-RG0740||Human PTGER3/Clytin Stable Cell Line-HEK293||PTGER3||Human||Epithelial||INQUIRY|