Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGE2 causes pain, vasodilatation, immunosuppression of T cells, bone resorption and promotion of carcinogenesis. Four related GPCRs, EP1, EP2, EP3 and EP4, each bind to PGE2, but the different G protein coupling status of each receptor leads to distinct biological effects. Further diversity is generated by alternative splicing; the human gene for EP3 generates 9 alternatively-spliced mRNAs encoding 8 isoforms of EP3. These isoforms of EP3 vary in sequence at their C-termini, and differ in their ability to couple to Gs, Gq or Gi. EP3 receptor activity is required for fever induced by pyrogens, a response long attributed to prostaglandins by the antipyretic action of aspirin and other COX inhibitors. In animal models of allergy, PGE2-mediated activation of EP3 inhibits inflammation to counteract the allergy-promoting activity of PGD2.
Product Information | |
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Catalog #: | ACC-RG0740 |
Gene Name | PTGER3 |
Abbr | HEK293-HuPTGER3/Clytin |
Alias | PTGER3,EP3,EP3e,EP3-I,EP3-II,EP3-IV,PGE2-R,EP3-III,MGC27302,MGC141828,MGC141829 |
Growth Properties | Adherent |
Host Cell | HEK293 |
Morphology | Epithelial |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | PTGER3,EP3,EP3e,EP3-I,EP3-II,EP3-IV,PGE2-R,EP3-III,MGC27302,MGC141828,MGC141829 |
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