Prostacyclin (PGI2) is released by vascular endothelial cells and serves as a potent vasodilator, inhibitor of platelet aggregation, and moderator of vascular smooth muscle cell proliferation-migration-differentiation. The function of protacyclin is mediated via a seven transmembrane GPCR, IP1, which is known to couple to Gs and Gq signaling pathways. Mice lacking the IP1 receptor have shown increased susceptibility to thrombosis, enhanced injury-induced vascular proliferation and platelet activation), as well as reperfusion injury. The recent world-wide withdrawal of selective COX-2 inhibitors, rofecoxib(Vioxx) and valdecoxib(Bextra), is also due to their discriminating suppression of COX-2-derived prostacyclin and IP1-mediated cardioprotective effects, leading to increased risk of cardiovascular events.
Product Information | |
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Catalog #: | ACC-RG0744 |
Gene Name | PTGIR |
Abbr | Chem-1-HuPTGIR/Galpha15 |
Alias | PTGIR,IP,PRIPR,MGC102830 |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | PTGIR,IP,PRIPR,MGC102830 |
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