Human S1PR5/Apoaequorin Stable Cell Line-CHO

Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of five G-protein-coupled receptors to regulate cell proliferation, migration, cytoskeletal organization, and differentiation. S1P5 can couple with Gi/o and G12/13, and it mediates S1P induced adenylate cyclase inhibition and Ca2+ mobilization like the other S1P receptors. However, unlike the other S1P receptors, it mediates inhibition of MAPK activation and cell proliferation. S1P5 is predominantly expressed in the white matter tracts and oligodendrocytes and is particularly abundant in the anterior commissure, corpus collosum, and optic tract. S1P induces process retraction in pre-oligodendrocytes and supports cell survival in mature oligodendrocytes by activating S1P5, which indicates a role for S1P5 in maturation and myelination of oligodendrocytes.

Product Information
Catalog #:	ACC-RG1299
Gene Name	S1PR5
Abbr	CHO-HuS1PR5/Apoaequorin
Alias	S1PR5,EDG8,Edg 8,S1P5,Edg-8,SPPR-1,SPPR-2
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	S1PR5,EDG8,Edg 8,S1P5,Edg-8,SPPR-1,SPPR-2