5-HT3 receptors are expressed throughout the central nervous system and peripheral nervous system and mediate a variety of physiological functions.
Fig. 1 5-HT3 receptor binding sites
Moreover, ligands that target the 5-HT3Rs are powerful therapeutic agents for the control and treatment of drug and alcohol dependence, schizophrenia, anxiety, and cognitive dysfunction, as well as chemotherapy-induced and post-operative nausea and vomiting.
Acroscell offers access to screening services for the following ligand-gated channel targets:
Tissue-specific Location: CNS and GI tract.
Therapeutic Targets: nausea and irritable bowel syndrome.
Description: The human HTR3B gene encodes subunit B of the type 3 serotonin receptor. This protein forms penta-heteromeric complexes with the 5-HT3A protein that modulate and influence pore function.