5-HT3 receptors are expressed throughout the central nervous system and peripheral nervous system and mediate a variety of physiological functions.

Fig. 1 5-HT3 receptor binding sites

Moreover, ligands that target the 5-HT3Rs are powerful therapeutic agents for the control and treatment of drug and alcohol dependence, schizophrenia, anxiety, and cognitive dysfunction, as well as chemotherapy-induced and post-operative nausea and vomiting.

Creative Bioarray offers access to screening services for the following ligand-gated channel targets:

5-HT3A (HTR3A)

Tissue-specific Location: CNS and GI tract.

Therapeutic Targets: nausea and irritable bowel syndrome.

5-HT3A/B (HTR3A/HTR3B)

Description: The human HTR3B gene encodes subunit B of the type 3 serotonin receptor. This protein forms penta-heteromeric complexes with the 5-HT3A protein that modulate and influence pore function.

Reference

1. Lummis SCR. 5-HT 3 Receptors. J Biol Chem. 2012; 287: 40239–40245.

Related Section

• Sodium Channels
• Calcium Channels
• Potassium Channels
• Chloride Channels
• TRP Channels
• ATP gated P2X Channels
• ASICs
• Nicotinic Acetylcholine Receptors
• Ionotropic Glutamate-gated Receptors
• GABAa Receptors
• Glycine Receptors
• Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
• Other Ion Channels