ATP-gated P2X receptor cation channel family , or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate. They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in multiple organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.
There are 7 known P2X subunits
P2X receptors are known as the purinergic receptors and have been indicated to play a role nociception, inflammation and airway hyperactivity.
Fig. 1 Antagonism of P2X receptor-mediated currents in rat mesenteric artery smooth muscle cells
Here in Creative Bioarray, we provide target screening on a series of P2X channels listed as below:
Tissue-specific Location: smooth muscle, platelets and sensory neurons.
Disease: P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation.
Therapeutic Targets: urinary incontinence and pain.
Tissue-specific Location: CNS, alveolar macrophages, vascular endothelium and airway smooth muscle.
Therapeutic Trgets: neuropathic pain, asthma and heart failure.
Tissue-specific location: lymphocytes and microglia.
Therapeutic targets: osteoporosis, neuropathic and inflammatory pain and also immune diseases.
Lewis CJ, Evans RJ. Lack of run-down of smooth muscle P2X receptor currents recorded with the amphotericin permeabilized patch technique, physiological and pharmacological characterization of the properties of mesenteric artery P2X receptor ion channels. Br J Pharmacol. 2000; 131: 1659–1666.