The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A mutation in the KCNJ2 gene has been shown to cause short QT syndrome. Expression of Kir2.1 gene in human HEK293 cells induce a transient outward current, creating a steady membrane potential of around -70 mV.

Fig. 1 Inhibitory effects of ML133 on Kir2.1 channels at different pH levels

Creative Bioarray currently provides manual patch clamp assay using acutely isolated animal cardiomyocytes or CHO-Kir2.1 cell line to test drug's inhibition or potentiating effect on Ik1 mainly contributed by Kir2.1 channels. This assay is one of the recommended preclinical cardiac safety assays in the pharmaceutical industry.

Here at Creative Bioarray, we provide drug targets screening on Kir 2.1 channels for cardiac safety evaluation. To test Kir2.1 as potential drug target, you can also customize your projects and contact our experienced scientists.

Reference

1. Wu M, et al. A potent and selective small molecule Kir2.1 inhibitor. Bethesda (MD), 2010.

Related Section

• HERG (IKR, KV11.1)
• Cav1.2
• Kv4.3
• KCNQ1/mink/Kv7.1
• Nav1.5
• Kv1.5
• HCN1&HCN4
• Other Ion Channels