Kv7.1 (KvLQT1) is a potassium channel protein (primary subunit in humans encoded by the KCNQ1 gene). Kv7.1 is a voltage-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cardiac action potential, terminating the cardiac action potential and thereby the heart's contraction.
Mutations in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome which is a prolongation of the QT interval of heart repolarization, short QT syndrome, and familial atrial fibrillation.
Fig. 1 Kv7.1 current amplitude is reduced by extracellular potassium
In Acroscell, our screening and concentration-response assays (IC50) of compounds for interactions with the KCNQ1/minK channel identify potential risk of QT prolongation in humans, and can be used as a screen in development candidate selection.