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Chloride Channels

Chloride Channels are a superfamily of poorly understood ion channels specific for chloride. Though the functions of CLC cytoplasmic domains are not fully characterized yet, their importance is illustrated by the pathologies resulting from their mutations.

Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.

Mutations of CLCN2 causes following genetic disorders:

  • Thomsen's disease
  • Dent's disease
  • Infantile malignantosteopetrosis
  • Bartter's syndrome

Creative Bioarray offers access to screening services for multiple chloride channel targets.

Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0010 Human GLRA1 Stable Cell Line-HEK293 GLRA1 Human Epithelial INQUIRY
ACC-RI0082 Human CLCN1 Stable Cell Line-CHO CLCN1 Human Epithelial-like INQUIRY
ACC-RI0003 Human CFTR Stable Cell Line-HEK293 CFTR Human Epithelial INQUIRY
ACC-RI0081 Human CFTR Stable Cell Line-CHO CFTR Human Epithelial-like INQUIRY
ACC-RI0084 Human CLCN2 Stable Cell Line-CHO CLCN2 Human Epithelial-like INQUIRY
ACC-RI0087 Human GABRA3/GABRB2/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0088 Human GABRA1/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0089 Human GABRA2/GABR2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0090 Human GABRA5/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0091 Human GABRA2/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
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For research use only.

Related Section

  • Sodium Channels
  • Calcium Channels
  • Potassium Channels
  • TRP Channels
  • ATP gated P2X Channels
  • ASICs
  • Nicotinic Acetylcholine Receptors
  • Ionotropic Glutamate-gated Receptors
  • GABAa Receptors
  • Glycine Receptors
  • 5-HT Receptors3
  • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
  • Other Ion Channels

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