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Chloride Channels

Chloride Channels are a superfamily of poorly understood ion channels specific for chloride. Though the functions of CLC cytoplasmic domains are not fully characterized yet, their importance is illustrated by the pathologies resulting from their mutations.

Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.

Mutations of CLCN2 causes following genetic disorders:

  • Thomsen's disease
  • Dent's disease
  • Infantile malignantosteopetrosis
  • Bartter's syndrome

Creative Bioarray offers access to screening services for multiple chloride channel targets.

Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0003 Human CFTR Stable Cell Line-HEK293 CFTR Human Epithelial INQUIRY
ACC-RI0004 Human GABRA1 Stable Cell Line-HEK293 GABRA1 Human Epithelial INQUIRY
ACC-RI0005 Human GABRA2 Stable Cell Line-HEK293 GABRA2 Human Epithelial INQUIRY
ACC-RI0006 Human GABRA3 Stable Cell Line-HEK293 GABRA3 Human Epithelial INQUIRY
ACC-RI0007 Human GABRA4 Stable Cell Line-HEK293 GABRA4 Human Epithelial INQUIRY
ACC-RI0008 Human GABRA5 Stable Cell Line-HEK293 GABRA5 Human Epithelial INQUIRY
ACC-RI0009 Human GABRA6 Stable Cell Line-HEK293 GABRA6 Human Epithelial INQUIRY
ACC-RI0010 Human GLRA1 Stable Cell Line-HEK293 GLRA1 Human Epithelial INQUIRY
ACC-RI0081 Human CFTR Stable Cell Line-CHO CFTR Human Epithelial-like INQUIRY
ACC-RI0082 Human CLCN1 Stable Cell Line-CHO CLCN1 Human Epithelial-like INQUIRY
ACC-RI0084 Human CLCN2 Stable Cell Line-CHO CLCN2 Human Epithelial-like INQUIRY
ACC-RI0087 Human GABRA3/GABRB2/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0088 Human GABRA1/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0089 Human GABRA2/GABR2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0090 Human GABRA5/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0091 Human GABRA2/GABRB2/GABRG2 Stable Cell Line-CHO GABRG2 Human Epithelial-like INQUIRY
ACC-RI0094 Human GABRA1/GABRB3/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0095 Human GABRA2/GABRB3/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0096 Human GABRA3/GABRB3/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0097 Human GABRA4/GABRB3/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
ACC-RI0098 Human GABRA5/GABRB3/GABRG2 Stable Cell Line-HEK293 GABRG2 Human Epithelial INQUIRY
For research use only.

Related Section

  • 5-HT3 receptors
  • ATP gated P2X Channels
  • Ionotropic Glutamate-gated Receptors
  • Other Ion Channels
  • AISCs

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