Structure and function of membrane channels are closely linked. Channelomic studies include the systematic study of diseases resulting from abnormalities of channel structure, which lead to physiological mis-function. Such a disease is termed a channelopathy.
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Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters. They are integral membrane proteins, typically formed as assemblies of several individual proteins.Learn More
Ion channel receptors are multimeric proteins, which usually locate in the plasma membrane. Each of those receptor proteins arranges itself in order to form a passageway or pore, so that to extend from one side of the membrane...Learn More
The ion channel superfamily plays central functional role in human physiology, and represents an attractive potential target class for drug discovery. The functional role is that ion channel mediates communication between...Learn More
Ion channels act as molecular transistors. Powered by ion concentration gradients, ion channels transduce a variety of signals into transmembrane ion fluxes. Ion channels have traditionally been...Learn More
Using tractable organisms to answer fundamental questions in medicine and biology has been a common practice since ancient times. One of the model systems with important contributions is the African clawed frog, a pseudotetraploid vertebrate living in freshwater.Learn More