Ionotropic glutamate receptors are ligand-gated ion channels which are activated by the neurotransmitter glutamate. Ionotropic glutamate receptors can be divided into 4 subgroups based on their pharmacology and sequence similarity.

• NMDA

• AMPA

• Kainite

• delta receptors

Ionotropic glutamate receptors mediate excitatory synaptic transmission throughout the central nervous systems and are involved in the synaptic plasticity of learning and memory.

Fig. 1. Distinct subpopulations of the NMDA receptor (NMDAR) mediate neuronal death and survival

Here in Creative Bioarray, we provide target screening on a series of ionotropic Glutamate-gated Receptors listed as below:

AMPA (GluA1) (GRIA1)

Functions: AMPA receptors play a key role in long term potentiation/ depression in hippocampal synapses.

Disease: GRIA1 mutations have been linked with limbic encephalitis.

NMDA (NR1/NR2A) (GluN1/GluN2A) (GRIN1/GRIN2A)

Therapeutic Targets: neurological disorders including seizure, pain and Alzheimer's disease.

NMDA (NR1/NR2B) (GluN1/GluN2B) (GRIN1/GRIN2B)

Therapeutic Targets: neurological disorders including seizure, pain and Alzheimer's disease.

NMDA (NR1/NR2D) (GluN1/GluN2D) (GRIN1/GRIN2D)

Therapeutic Targets: neurological disorders including seizure, pain and Alzheimer's disease.

Reference

1. Lai TW, et al. Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol 2014; 115: 157–188.

Related Section

• Sodium Channels
• Calcium Channels
• Potassium Channels
• Chloride Channels
• TRP Channels
• ATP gated P2X Channels
• ASICs
• Nicotinic Acetylcholine Receptors
• GABAa Receptors
• Glycine Receptors
• 5-HT Receptors3
• Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
• Other Ion Channels