As key components in a wide variety of biological processes involved in rapid changes in cells (e.g. cardiac/skeletal/smooth muscle contraction, and epithelial transport of nutrients), ion channels are important therapeutic targets in a range of indications, including cardiac, central nervous system, immune system and metabolic diseases. A great increase in interest of ion channels as drug targets was raised due to the recent development of successful new screening technologies.
Fig.1 Schematic illustration of distinct ion channels in SN DA neurons
Ion channel screening programs require strong electrophysiological support. With innovative technology platforms, our talented scientists are confident in offering high-efficiency service for your ion channel drug discovery programs with the most competitive price. Acroscell can test your compounds for ion channel selectivity, develop new cell lines expressing ion channels of interest to your discovery program or validate existing ion channel-expressing cell lines. An extensive panel of ion channel screening assays with more than 80 ion channel targets and over 200 ion channel assays included are available in Acroscell. To quickly and accurately provide results for drug discovery, Acroscell can offer a wide range of binding or functional assays for ion channel screening analysis.
Conventional patch-clamp electrophysiology
Over ten years' experience in this field has enabled Acroscell to better understand our customers' latent demands. Our scientific experts are ready to reduce the risk and maximize the success of your discovery programs. Through conducting against ion channels from a large collection expressed in mammalian cells, a compound's ion channel potency, efficacy, specificity or potential for off-target effects can also be high-throughput identified in early drug discovery at Acroscell. Moreover, for screening and profiling ion channel targets, off-the-shelf or custom assays are offered as well in Acroscell.
Whether you are doing High Throughput Screening (HTS) or lead optimization against your target of interest, Acroscell can provide a validated assay and platform fit for the purpose. A customized panel can be available consisting of any single channel or combination of channels to be tested in our flexible service. We can use your specified concentration range and assay protocol as well if desired. As a well-recognized provider in ion channel related services, Acroscell is pleased to tailor the best-fit protocol to meet your specific demands and also facilitate your research and project development.
Comprehensive screening library: Including cardiac ion channels, central/peripheral nervous system ion channels, transporters or exchangers, etc.
Convenience: Using automated electrophysiology will help you save compounds. For testing hERG activity, a single dose only requires less than 10μL of 10mM stock and less than 100 μL of 10 mM stock was needed in most dose-response experiments.
Timeliness: Since time is of the essence in most drug discovery projects, we offer you high quality data in a timely fashion, thanks to our fast turnaround and guaranteed delivery.
Flexibility：For IC50 determination tests, single concentration testing or different formats of multiple concentration all depends on your program's requirement.
Efficient electrophysiology support: Testing your compounds at Acroscell will add electrophysiology support and expertise to your drug discovery programs. Acroscell goes beyond the simple testing: if you need help in interpreting and making sense of the electrophysiology data, our scientists will share their expertise with you and answer your questions. We make your success our priority.
Fig. 2 Steps in early drug/probe discovery. Translational programs require stringent target identification and validation information.
If you have any special needs in our Ion channel screening service, please contact us at email or Telephone for this special service. Let us know what you need and we will accommodate you. We look forward to working with you in the future.
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Dragicevic, E., et al. Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. 2015; 284, 798-814.
Roy A. Early Probe and Drug Discovery in Academia: A Minireview. High-Throughput. 2018;7:4.