Potassium voltage-gated channel subfamily D member 3 (Kv4.3) is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. Kv4.3 is a member of the Shal family of Kv channels and generates a rapidly activating and rapidly inactivating current, contributing to the transient outward K+ current in the heart.
This channel may be an important therapeutic target for certain anti-arrhythmic drugs.
Fig. 1 Effect of ranolazine on steady-state inactivation of Kv4.3
Acroscell provides manual and auto patch clamp functional assay to evaluate drug's inhibition or potentiation effect on Kv4.3 channel. In this assay, HEK293-Kv4.3 cells are used to specifically assess the effect of test compounds.
Here at Acroscell, Kv4.3 analysis is included in our CiPA service package, and for its target-specific screening, we provide manual or automated patch-clamp recording services to determine your drug effects on Kv4.3. To test the potential Kv4.3 drug target, you can customize your projects and contact our experienced scientists.