Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common condition is increasingly recognized as a heritable disorder. Genomic DNA scanning revealed a nonsense mutation in KCNA5 that encodes Kv1.5, a voltage-gated potassium channel expressed in human atria. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death.

Fig. 1 Loss-of-function E375X mutation exerts a dominant-negative effect on Kv1.5 function

Staffed with a group of experts that have gained years of experience in ion channel safety assays and cardiotoxicity assessment, Creative Bioarray offers screening analysis and concentration-response assays (IC₅₀) of compounds inhibit Kv1.5 to evaluate compound cardiovascular safety and this service can be used as a screen in development candidate selection.

Reference

1. Olson TM, et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum. Mol. Genet. 2006; 15: 2185–2191.

Related Section

• HERG (IKR, KV11.1)
• Cav1.2
• Kv4.3
• KCNQ1/mink/Kv7.1
• Kir2.1
• Nav1.5
• HCN1&HCN4
• Other Ion Channels