Atrial ﬁbrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common condition is increasingly recognized as a heritable disorder. Genomic DNA scanning revealed a nonsense mutation in KCNA5 that encodes Kv1.5, a voltage-gated potassium channel expressed in human atria. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death.
Fig. 1 Loss-of-function E375X mutation exerts a dominant-negative effect on Kv1.5 function
Staffed with a group of experts that have gained years of experience in ion channel safety assays and cardiotoxicity assessment, Acroscell offers screening analysis and concentration-response assays (IC50) of compounds inhibit Kv1.5 to evaluate compound cardiovascular safety and this service can be used as a screen in development candidate selection.