Patch-clamp Assay
From single neuron down to single channel, thanks to the different recording configurations (whole-cell, perforated-patch, cell-attached, outside-out), patch-clamp techniques provide the highest resolution for electrophysiological recordings in ion channel screening process. In Creative Bioarray, we provide manual and automated patch-clamp techniques for ion channel target scanning.
Advantages
Gold-standard in ion channel researches
Most reliable and resolutive method to study ionic channels
Very precise physiological and pharmacological questions could be addressed with this technique
Clearly dedicated to the understanding of mechanisms of action
Virtually all ionic channels in the body: ligand-gated, voltage-gated, calcium-gated, fast/slow activating and deactivating, can be studied
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