Fluorescence assays employ membrane potential dye or FRET-based voltage senor to measure fluorescence changes caused by dye relocation in response to membrane potential depolarization or hyperpolarization following ion channel activation or inhibition.
In Acroscell, our high throughput ion channel screening team incorporate to design, optimize and run ion channel High Throughput Screening programs with a clear focus on ensuring meaningful data and successful outcomes within client-driven timelines.
Fluorescence-based FLIPR assays
Automated 384-well electrophysiology
With a dedicated ion cell biology team on hand, Acroscell can rapidly screen compounds against even the most challenging ion channel targets.
Fig. 1 Pipeline of high-throughput screening targeting ion channels
Haibo, Y., et al. High throughput screening technologies for ion channels, Acta Pharmacologica Sinica. 2016; 37: 34-43