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Sodium Channels

Sodium channels are that form ion channels, conducting sodium ions (Na+) through cellular plasma membrane. Voltage-gated sodium channels (also called "VGSCs" or "Nav channel") are present in the membrane of most excitable cells and are involved in many cardiac or neuronal diseases.


1-2-1 Sodium Channels-1.jpg

Fig.1 Sodium channels α-subunit


Sodium channels are the main component and responsible for the rising phase of action potentials in excitable cells such as neurons, myocytes, and some certain types of glia. The dynamics of sodium channels can be classified into three different states: resting, active and inactive states.

Functions

  • Mediating the sodium ion permeability of excitable membranes in a voltage-dependent form.

  • Forming a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

  • Assuming opened or closed conformations in response to the voltage difference across the membrane.

  • Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons.

  • Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.

Genetic mutations that cause persistent activity in sodium channels can cause disease by creating excessive activity of certain kinds of neurons. Mutations that interfere with Na+ channel inactivation can contribute to cardiovascular diseases or epileptic seizures by window currents, which can cause muscle and/or nerve cells to become over-excited.


1-2-1 Sodium Channels-2.jpg

Fig. 2 Pathological consequences of acquired and/or inherited Na+ channelopathies


The specific tissue localizations of sodium channels

  • Central nervous system, peripheral neurons and dorsal root ganglia
    9 known members: Nav1.1- Nav1.9

  • Cardiac myocytes
    Nav1.5

  • Skeletal muscle
    Nav1.4

Here in Creative Bioarray, we provide target screening on a series of sodium channels listed as below:

Nav1.1 (SCN1A)

Disease: mutations in SCN1A are responsible for many types of epilepsies (generalized epilepsy with febrile seizures, severe myoclonic epilepsy in infancy) and some forms of familial hemiplegic migraine.

Therapeutic Targets: seizure, stroke and pain.

Nav1.2 (SCN2A)

Disease: mutations are associated with benign familial neonatal-infantile seizures.

Therapeutic Targets: seizure, stroke and pain.

Nav1.3 (SCN3A)

Disease: upregulated in nerve injury.

Therapeutic Targets: seizure and pain.

Nav1.5 (SCN5A)

Tissue-specific Location: heart and upregulated in breast cancer cells.

Disease: mutations in SCN5A are responsible for some forms of long QT and short QT syndromes, progressive cardiac conduction defect, sick sinus node syndrome, and dilated cardiomyopathy, Brugada syndrome (BrS), congenital heart block.

Therapeutic Target: anti-targets in cardiac risk assessment.

Nav1.6 (SCN8A)

Tissue-specific Location: central and peripheral nervous systems.

Disease: Mutations in the mouse ortholog cause ataxia and other movement disorders.

Therapeutic Target: multiple sclerosis and seizure.

Nav1.7 (SCN9A)

Disease: mutations in this channel are associated with primary erythromelalgia, insensitivity to pain and paroxysmal extreme pain disorder.

Therapeutic Target: pain treatment and nociceptive disorders.

Nav1.8 (SCN10A)

Disease: upregulated in chronic/inflammatory pain.

Therapeutic Target: pain treatment.


Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0168 Human SCN8A Stable Cell Line-CHO SCN8A Human Epithelial-like INQUIRY
ACC-RI0055 Rat Nav1.8 Stable Cell Line-ND7-23 Nav1.8 Rat Neuronal INQUIRY
ACC-RI0054 Human SCN10A Stable Cell Line-HEK293 SCN10A Human Epithelial INQUIRY
ACC-RI0053 Human SCN9A Stable Cell Line-HEK293 SCN9A Human Epithelial INQUIRY
ACC-RI0052 Human SCN8A Stable Cell Line-HEK293 SCN8A Human Epithelial INQUIRY
ACC-RI0051 Human SCN5A Stable Cell Line-HEK293 SCN5A Human Epithelial INQUIRY
ACC-RI0050 Human SCN4A Stable Cell Line-HEK293 SCN4A Human Epithelial INQUIRY
ACC-RI0049 Human SCN3A Stable Cell Line-CHO SCN3A Human Epithelial-like INQUIRY
ACC-RI0048 Human SCN2A Stable Cell Line-CHO SCN2A Human Epithelial-like INQUIRY
ACC-RI0047 Human SCN1A Stable Cell Line-HEK293 SCN1A Human Epithelial INQUIRY
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For research use only.

Related Section

  • Calcium Channels
  • Potassium Channels
  • Chloride Channels
  • TRP Channels
  • ATP gated P2X Channels
  • ASICs
  • Nicotinic Acetylcholine Receptors
  • Ionotropic Glutamate-gated Receptors
  • GABAa Receptors
  • Glycine Receptors
  • 5-HT Receptors3
  • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
  • Other Ion Channels

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