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Other Ion Channels

In addition to ion channel families such as voltage-gated sodium, calcium and potassium channels and ligand-gated TRP channels, a number of other ion channel/transporters or exchangers play key roles in health and disease. For example, membrane exchangers are involved in numerous vital cell functions, such as excitability, excitation-contraction coupling, energy metabolism, pHi and volume regulation, development and growth.


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Fig. 1 Multiple ion channels and calcium exchangers are involved in cardiomyocytes Excitation-Contraction Coupling (E-C coupling)


Here we give an example of Na+/Ca2+ exchangers (NCX), other ion channel assay projects can also be customized by our experienced scientists.

In a number of cardiac and neural pathologies, the intracellular Na+ ([Na+]i) is elevated. Since [Na+]i and intracellular Ca2+ concentration ([Ca2+]i) are coupled through the NCX, these pathologies display disturbed [Ca2+]i handling. Pharmacological intervention with [Na+]i and [Ca2+]i homeostasis might prevent hypertrophy, cardiac remodeling, arrhythmias, heart failure, cardiac and cerebral ischemia.

Creative Bioarray uses digital cell Ca2+ imaging with multiple Ca2+ dyes (eg, Fura-2 AM) in single human living cells to perform assays for several Na+/Ca2+ exchangers, including NCX and Na+/Ca2+plus K+ exchangers (NCKX). We also provide services to test effects of lead compounds on activity of these exchangers in both cell lines overly expressing NCX/NCKX and primary human cells.


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Fig. 2 The effect of LCA on INCX in rat SMCs


References

  1. Garcia-Elias, A., & Benito, B. Ion Channel Disorders and Sudden Cardiac Death. Int J Mol Sci. 2018; 19:692

  2. Zhu J, et al. Hydrophobic bile acids relax rat detrusor contraction via inhibiting the opening of the Na+/Ca2+ exchanger. Sci Rep. 2016; 6: 1–9.

Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0011 Human HCN1 Stable Cell Line-HEK293 HCN1 Human Epithelial INQUIRY
ACC-RI0012 Human HCN2 Stable Cell Line-HEK293 HCN2 Human Epithelial INQUIRY
ACC-RI0013 Human HCN3 Stable Cell Line-HEK293 HCN3 Human Epithelial INQUIRY
ACC-RI0014 Human HCN4 Stable Cell Line-CHO HCN4 Human Epithelial-like INQUIRY
ACC-RI0100 Human HCN2 Stable Cell Line-CHO HCN2 Human Epithelial-like INQUIRY
ACC-RI0102 Human HCN4 Stable Cell Line-HEK293 HCN4 Human Epithelial INQUIRY
ACC-RI0099 Human HCN1 Stable Cell Line-HEK293, tetracycline-inducible HCN1 Human Epithelial INQUIRY
For research use only.

Related Section

  • Sodium Channels
  • Calcium Channels
  • Potassium Channels
  • Chloride Channels
  • TRP Channels
  • ATP gated P2X Channels
  • ASICs
  • Nicotinic Acetylcholine Receptors
  • Ionotropic Glutamate-gated Receptors
  • GABAa Receptors
  • Glycine Receptors
  • 5-HT Receptors3
  • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)

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