Electroencephalography (EEG) is one of the most commonly used methods to measure brain activity in humans and lab animals. Surface EEG signal depends on both the amplitude and spatial synchronization of underlying neural activity.

Noninvasive EEG measurements are easily combined with other techniques like behavior testing and micro-dialysis. Understanding the effects of test compounds on the activity and function of the brain are essential in drug development, continuous EEG following acute or chronic compound treatment in combination with multiple animal model researches and behavioral testing.

Fig. 1 Effects of lidocaine on single-trial EEG and LFP

Here in Creative Bioarray, we use EEG monitoring to assess changes in sleep state and electrical activity associated with neurological disease models. Using a telemetric approach, EEG patterns indicative of changes in underlying neuronal function are recorded and show specific rhythmic activity that can be used as characteristic translational biomarkers.

Reference

1. Musall S, et al. Effects of neural synchrony on surface EEG. Cereb Cortex. 2014; 24: 1045–1053.

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