Potassium voltage-gated channel subfamily D member 3 (Kv4.3) is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. Kv4.3 is a member of the Shal family of Kv channels and generates a rapidly activating and rapidly inactivating current, contributing to the transient outward K⁺ current in the heart.

This channel may be an important therapeutic target for certain anti-arrhythmic drugs.

Fig. 1 Effect of ranolazine on steady-state inactivation of Kv4.3

Creative Bioarray provides manual and auto patch clamp functional assay to evaluate drug's inhibition or potentiation effect on Kv4.3 channel. In this assay, HEK293-Kv4.3 cells are used to specifically assess the effect of test compounds.

Here at Creative Bioarray, Kv4.3 analysis is included in our CiPA service package, and for its target-specific screening, we provide manual or automated patch-clamp recording services to determine your drug effects on Kv4.3. To test the potential Kv4.3 drug target, you can customize your projects and contact our experienced scientists.

Reference

1. Jeong I, et al. Effects of fluoxetine on cloned Kv4. 3 potassium channels. Brain Res. 2013; 1500: 10–18.

Related Section

• HERG (IKR, KV11.1)
• Cav1.2
• KCNQ1/mink/Kv7.1
• Kir2.1
• Nav1.5
• Kv1.5
• HCN1&HCN4
• Other Ion Channels