LTP & LTD Formation or Deficit Detection
Long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression (LTD), which produces a long-lasting decrease in synaptic strength.
Fig. 1 Molecular players and mechanisms involved in AMPAR trafficking during Hebbian plasticity
It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength. As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory. LTP is also a subject of clinical research, for example, in the areas of Alzheimer's disease and addiction medicine.
Fig.2 LTP and LTD Induction protocols
To evaluate drug effects on neuronal transmission, here in Creative Bioarray, we measure LTP and LTD both in vivo and in vitro from rat and mouse brains. Studies are performed by both manual patch clamp or MEA.
References
Vitureira N, Goda Y. The interplay between Hebbian and homeostatic synaptic plasticity. J Cell Biol. 2013, 203: 175-186.
Bliss T V P, Cooke S F. Long-term potentiation and long-term depression: a clinical perspective. Clinics. 2011, 66: 3-17.
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