The corticotropin-releasing factor receptors, CRF1 and CRF2, are Gs-coupled GPCRs expressed in the brain, blood vessels and intestine that bind to several neuropeptides, including corticotropin-releasing factor (CRF) and urocortin, and the amphibian peptide sauvagine. In addition, two peptides, urocortin II (Ucn II) and urocortin III (Ucn III), bind selectively and with high affinity to CRF2. The CRF peptides and their receptors play important roles in stress mediated by the hypothalamic-pituitary-adrenal axis in animal models, and possibly in depression and anxiety in humans, although the contributions of CRF1 and CRF2 appear to be distinct. In addition, CRF1 and CRF2 differentially alter feeding behavior, gastric motility and vascular tone.
Product Information | |
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Catalog #: | ACC-RG0649 |
Gene Name | CRHR2 |
Abbr | Chem-1-HuCRHR2/Galpha15 |
Alias | CRHR2,CRF-RB,CRF2,CRFR2,HM-CRF |
Growth Properties | Adherent |
Host Cell | Chem-1 |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | CRHR2,CRF-RB,CRF2,CRFR2,HM-CRF |
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