The metabotropic glutamate receptors (mGluRs) are divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. Group II and group III mGluRs are linked to inhibition of the cyclic AMP cascade, but differ in their agonist selectivity. mGluR5 is a member of Group I. It mainly expresses the brain although its precise role in various cortical functions remains unclear.
|Product Type||GPCR Expressing Cell|