GPR109A (HM74A, PUMA-G or niacin receptor 1) is a high-affinity receptor for nicotinic acid (niacin), and is highly expressed in adipocytes, lung, macrophages, dendritic cells, microglia and neutrophils. GPR109A in adipocytes is likely to be involved in niacinmediated inhibition of lipolysis, reduction of serum free fatty acids and triglycerides as well as elevation of high density lipoproteins. GPR109A also serves important functions in the immune system. GPR109A on Langerhans cells in the skin also mediates niacin-induced cutaneous flushing, one of the major side effects of niacin, via the massive production of prostaglandins PGD2 and PGE2 in a ligand-dependent fashion.

Product Information
Catalog #:	ACC-RG0337
Gene Name	HCAR2
Abbr	CHO-HuHCAR2-FLAG
Alias	HCAR2,GPR109A,HCA2,HM74A,NIACR1,PUMAG,HM74a,HM74b,Puma-g,GPR109A
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	HCAR2,GPR109A,HCA2,HM74A,NIACR1,PUMAG,HM74a,HM74b,Puma-g,GPR109A

Related Products

Catalog	Product Name	Gene Name	Species	Morphology	Price
ACC-RG1680	Human HCAR2 Stable Cell Line-CHO-K1/Gα15	HCAR2	Human		INQUIRY
ACC-RG1315	Human HCAR2/Apoaequorin Stable Cell Line-CHO	HCAR2	Human	Epithelial-like	INQUIRY
ACC-RG1193	Human HCAR2 Validated Stable Cell Line-CHO	HCAR2	Human	Epithelial-like	INQUIRY