5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. The 5-HT2B receptor, which couples to Gq/11 to increase intracellular calcium, is expressed in embryonic and adult cardiovascular tissues, gut and brain from the rat, mouse, and human species. A role for 5-HT2B receptors was suggested in the cardiopathy associated with fenfluramine.
|Alias||HTR2B,5 HT(2B),5 HT2B,5-HT-2B,5-HT2B,5-HT(2B)|
|Product Type||GPCR Expressing Cell|
|Catalog||Product Name||Gene Name||Species||Morphology||Price|
|ACC-RG0387||Human HTR2B-FLAG Stable Cell Line-HEK293T||HTR2B||Human||Epithelial||INQUIRY|
|ACC-RG0388||Human HTR2B-FLAG Stable Cell Line-CHO||HTR2B||Human||Epithelial-like||INQUIRY|
|ACC-RG0779||Human HTR2B Stable Cell Line-CHO||HTR2B||Human||Epithelial-like||INQUIRY|
|ACC-RG1535||Human HTR2B/beta-Arrestin Stable Cell Line-HEK293||HTR2B||Human||Epithelial||INQUIRY|