Leukotriene B4 (LTB4) is a potent lipid mediator of allergic and inflammatory reactions, as well as a modulator of immune responses. Two types of plasma membrane receptors for LTB4 have been described on human neutrophils. The high-affinity human leukocyte LTB4 receptor, BLT1 (or LTB4R) mediates aggregation, chemotaxis, chemokinesis, and increased adherence to surfaces, whereas the low-affinity receptor mediates degranulation and increased oxidative metabolism. BLT1 mRNA is expressed in leukocytes and to a lesser degree in spleen and thymus. Studies in mice with disrupted BLT1 gene indicate a major role for BLT1 in acute inflammation and immediate hypersensitivity, as well as in leukocyte functions such as chemotaxis and firm adhesion to endothelium in response to LTB4.

Product Information
Catalog #:	ACC-RG0445
Gene Name	LTB4R
Abbr	HEK293T-HuLTB4R-FLAG
Alias	LTB4R,CMKRL1,GPR16,P2RY7,BLTR,LTB4R1,P2Y7,LTB4-R1,LTB4-R 1,BLT1,GPR16,LTBR1,P2RY7,CMKRL1
Growth Properties	Adherent
Host Cell	HEK293T
Morphology	Epithelial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	LTB4R,CMKRL1,GPR16,P2RY7,BLTR,LTB4R1,P2Y7,LTB4-R1,LTB4-R 1,BLT1,GPR16,LTBR1,P2RY7,CMKRL1

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