Leukotriene B4 (LTB4) is a potent lipid mediator of allergic and inflammatory reactions, as well as a modulator of immune responses. Two receptors for LTB4 have been described on human neutrophils. The high-affinity human leukocyte LTB4 receptor, BLT1 mediates aggregation, chemotaxis, chemokinesis, and increased adherence to surfaces, whereas the low-affinity receptor, BLT2 (or LTB4R2) mediates degranulation and increased oxidative metabolism. BLT2 is expressed ubiquitously with the highest expression in spleen and has a broader ligand specificity for various eicosanoids. Cells expressing BLT2 exhibited LTB4-induced chemotaxis, calcium mobilization, and inhibition of adenylyl cyclase. BLT2 provides a novel target for anti-inflammatory therapy and promises to
expand our knowledge of LTB4 function.

Product Information
Catalog #:	ACC-RG0280
Gene Name	LTB4R2
Abbr	HEK293T-HuLTB4R2-FLAG
Alias	LTB4R2,BLT2,BLTR2,JULF2,NOP9,KPG_004,LTB4-R2,LTB4-R 2
Growth Properties	Adherent
Host Cell	HEK293T
Morphology	Epithelial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	LTB4R2,BLT2,BLTR2,JULF2,NOP9,KPG_004,LTB4-R2,LTB4-R 2