Prostaglandin E2 (PGE2) is involved in a number of physiologic and pathophysiologic events in many tissues of the body. The biologic effects of PGE2 are mediated through interaction with specific membrane-bound G protein-coupled prostanoid EP receptors. EP3 receptor (or PTGER3) is expressed as multiple transcripts through alternative splicing, with each transcript showing a different tissue-specific distribution. PGE2 may mediate fever generation in response to both endogenous and exogenous pyrogens by acting at the EP3 receptor. EP3-mediated neuronal pathways converge at corticotropin-releasing hormone containing neurons in the paraventricular nucleus of the hypothalamus to induce HPA axis activation during sickness.
Product Information | |
---|---|
Catalog #: | ACC-RG0361 |
Gene Name | PTGER3 |
Abbr | CHO-HuPTGER3-FLAG |
Alias | PTGER3,EP3,EP3e,EP3-I,EP3-II,EP3-IV,PGE2-R,EP3-III,MGC27302,MGC141828,MGC141829 |
Growth Properties | Adherent |
Host Cell | CHO-K1 |
Morphology | Epithelial-like |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | PTGER3,EP3,EP3e,EP3-I,EP3-II,EP3-IV,PGE2-R,EP3-III,MGC27302,MGC141828,MGC141829 |
Inquiry