RAMP2 (Receptor Activity Modifying Protein 2) is a Protein Coding gene. Diseases associated with RAMP2 include Pheochromocytoma. Among its related pathways are Presynaptic function of Kainate receptors and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP3. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. CALCR (Calcitonin Receptor) is a Protein Coding gene. Diseases associated with CALCR include Osteoporosis and Bone Mineral Density Quantitative Trait Locus 15. Among its related pathways are Presynaptic function of Kainate receptors and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity.
|Product Type||GPCR Expressing Cell|
|Product Format||Liquid nitrogen|