Human SUCNR1/Apoaequorin Stable Cell Line-CHO

GPR91 is a class A G-protein coupled receptor that binds selectively to succinate, an intermediate in the citric acid cycle, and couples to both the Gi/Go and Gq pathways. Renal proximal tubules are a major site of GPR91 expression, and succinate-mediated activation of renal GPR91 stimulates the release of renin to cause vasoconstriction and hypertension. In addition, GPR91 in retinal neurons mediates retinal vascularization induced by succinate, which accumulates in response to hypoxia. Dendritic cells also highly express GPR91, which mediates succinate-induced immune cell migration and activation in vitro and in vivo. Therefore, suppression of GPR91 is a potential strategy for treatment of vascular retinopathies, hypertension, and inflammation.

Product Information
Catalog #:	ACC-RG1288
Gene Name	SUCNR1
Abbr	CHO-HuSUCNR1/Apoaequorin
Alias	SUCNR1,GPR91
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	SUCNR1,GPR91